TV and or Movie damsels bound and gagged once but significant

[Reidy]

Gemma Arterton in The Disappearance of Alice Creed must be the gold standard.

[illest]

I wanted to say Elizabeth Taylor in The Flintstones movie until my research led me to the startling discovery that it was definitely not her first "rodeo"

[Kyle]

That's some awful vague criteria.

[drgoremd]

Hailey Foster in "My Uncle the Alien". It was her first and only movie according to IMDB